Production of the Hepatotoxic Chlorine-Containing Peptide by Penicillium islandicum Sopp
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چکیده
منابع مشابه
Production of the hepatotoxic chlorine-containing peptide by Penicillium islandicum Sopp.
Twenty-six strains of Penicillium islandicum Sopp were tested for production of a chlorine-containing peptide (Cl-peptide), which is a hepatotoxin. Highest levels of the mycotoxin were produced in a modification of Wickerham medium. The mycotoxin was isolated by adsorption on charcoal and, after washing the charcoal with acetone-water (1:1), was eluted into n-butanol. Further purification was a...
متن کاملProduction of luteoskyrin, a hepatotoxic pigment, by Penicillium islandicum Sopp.
Various factors affecting the yields of luteoskyrin, a hepatotoxic mycotoxin, and related pigments in the liquid medium were studied. Maximal yields of luteoskyrin (0.13% by isolation) and of other pigments were attained in the late phase of the cultivation. The yield of the pigment was increased by supplying malt extract, malonic acid, glutamic acid, or asparagine. A useful material for prepar...
متن کاملProduction of luteoskyrin and isolation of a new metabolite, pibasterol, from Penicillium islandicum Sopp.
Production of luteoskyrin, a hepatotoxin synthesized by Penicillium islandicum Sopp., was studied with various fermentation methods. Best results were obtained in static fermentations on glutinous rice at 30 degrees C. The isolated yield of pure luteoskyrin was approximately 400 mg per kg of rice. Also produced were skyrin, islandicin, iridoskyrin, rubroskyrin, chrysophanol, mannitol, and eryth...
متن کاملBiotin and the biosynthesis of anthraquinoid pigments in Penicillium islandicum Sopp.
By use of liver enzyme preparations, it has been proved that biotin is required for the synthesis of fatty acids (S. J. Wakil, Lipid Res. 2:1, 1961). Biotin-containing enzyme, acetyl-coenzyme A (CoA) carboxylase, catalyzes the first step in the reaction, and the malonyl-CoA produced is the first intermediate of the biosynthesis of the anthraquinoid pigment in fungi (S. Gatenbeck, Acta Chem. Sca...
متن کاملThe cyclochlorotine mycotoxin is produced by the nonribosomal peptide synthetase CctN in Talaromyces islandicus ('Penicillium islandicum').
Talaromyces islandicus ('Penicillium islandicum') is a widespread foodborne mold that produces numerous secondary metabolites, among them potent mycotoxins belonging to different chemical classes. A notable metabolite is the hepatotoxic and carcinogenic pentapeptide cyclochlorotine that contains the unusual amino acids β-phenylalanine, 2-aminobutyrate and 3,4-dichloroproline. Although the chemi...
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ژورنال
عنوان ژورنال: Applied Microbiology
سال: 1973
ISSN: 0003-6919
DOI: 10.1128/am.26.3.359-363.1973